Table 1.
Comparisons of baseline characteristics of healthy control (HC), HBV-related liver cirrhosis (LC) and HBV-related liver cirrhosis complicated with severe sepsis (LC + SS) groups
| Parameter | HC (n = 17) | LC (n = 30) | LC + SS (n = 70) | |
|---|---|---|---|---|
| Age (years) | 58 (48-64) | 48 (39-57) | 53 (47-60) | |
| Male/total (%) | 10/17 (58.8) | 21/30 (70.0) | 49/70 (70.0) | |
| WBC (× 109/l) | 5.82 (4.89-7.73) | 3.46 (2.55-5.84) | 8.84 (5.60-12.67)* | |
| Lymphocytes (× 109/l) | 2.43 (1.98-3.16) | 1.01 (0.76-1.39)# | 0.83 (0.54-1.21)#* | |
| SOFA score | – | – | 10 (8-12) | |
| CLIF-SOFA score | – | – | 13 (10-15) | |
| PD-L1 percentage on CD14+ monocytes (%) | 3.10 (1.40-6.56) | 11.91 (2.24-28.62)# | 20.05 (8.56-41.90)#* | |
| PD-L1 MFI on CD14+ monocytes (%) | 2.72 (2.46-2.92) | 2.75 (2.55-3.06) | 2.97 (2.64-3.35)#* | |
| HBV viral load log (IU/ml) (n = 42) | – | 3.2 (2-4.6) | 3.6 (2.2-4.6) | |
| Culture results | ||||
| G+ cocci, n (%) | – | 3 (10.0) | 19 (27.1) | |
| G– bacilli, n (%) | – | 2 (6.7) | 11 (15.7) | |
| Mixed infection, n (%) | – | 0 (0) | 8 (11.4) | |
| Fungi, n (%) | – | 0 (0) | 5 (7.1) | |
| Anaerobes, n (%) | – | 0 (0) | 1 (1.4) | |
#
Comparing with the HC group with p < 0.05, *comparing with the LC group with p < 0.05. Significance was set at p < 0.05 bilaterally. Quantitative data were presented as medians (M) and interquartile ranges. Qualitative data were reported as frequencies and percentages.