Table 4:

Physical Features Compared with Age of Growth Hormone (GH) Treatment Initiation

Age of initiation of GH (years)	0 – 1 N= 121		1 – 4 N=84		4 – 12 N=52		12 – 21 N=19		21 – 70 N=13		Chi-Square p-value
	N	%	N	%	N	%	N	%	N	%
HEAD AND FACE:
Prominent occiput	15	13.9	12	15.8	5	10.2	2	11.8	2	15.4	0.928
Flat occiput	34	31.5	19	25.0	15	30.6	2	11.8	3	23.1	0.471
Round face	25	23.1	23	30.3	18	36.7	5	29.4	1	7.7	0.198
Narrow nose	22	20.4	22	28.9	22	44.9	7	41.2	6	46.2	0.013
Bitemporal narrowing	81	75.0	54	71.1	32	65.3	13	76.5	12	92.3	0.355
Craniosynostosis	3	2.8	0	0.0	0	0.0	0	0.0	0	0.0	0.360
Hypopigmented hair	50	46.3	23	30.3	15	30.6	8	47.1	3	23.1	0.089
Hyperpigmented hair	2	1.9	1	1.3	2	4.1	0	0.0	1	7.7	0.521
CHIN:
Micrognathia	24	22.2	18	23.7	5	10.2	6	35.3	6	46.2	0.039
Prognathia	11	10.2	5	6.6	8	16.3	2	11.8	0	0.0	0.317
Retrognathia	7	6.5	6	7.9	3	6.1	0	0.0	0	0.0	0.661
EYES:
Almond-shaped	61	56.5	46	60.5	31	63.3	10	58.8	8	61.5	0.945
Slit-like eyes	5	4.6	5	6.6	8	16.3	4	23.5	2	15.4	0.025
Strabismus	61	56.5	40	52.6	22	44.9	7	41.2	5	38.5	0.467
Esotropia	53	49.1	40	52.6	18	36.7	6	35.3	5	38.5	0.341
Exotropia	6	5.6	3	3.9	4	8.2	4	23.5	1	7.7	0.065
Ptosis	15	13.9	11	14.5	10	20.4	3	17.6	4	30.8	0.515
Epicanthal folds	38	35.2	22	28.9	11	22.4	5	29.4	3	23.1	0.549
Hypertelorism	8	7.4	7	9.2	3	6.1	1	5.9	0	0.0	0.809
Hypotelorism	9	8.3	11	14.5	7	14.3	2	11.8	0	0.0	0.424
EXTREMITIES:
Short fifth fingers	23	21.3	24	31.6	23	46.9	4	23.5	4	30.8	0.026
BACK:
Kyphosis	5	4.6	11	14.5	17	34.7	4	23.5	7	53.8	<0.05
ABDOMEN:
Abdominal (central) distribution of fat (Central)	44	40.7	53	69.7	32	65.3	11	64.7	12	92.3	<0.05