Skip to main content
. 2021 Nov 4;16(11):e0259212. doi: 10.1371/journal.pone.0259212

Table 2. Cox-proportional hazards regression model for cardiovascular diseases, cerebrovascular diseases, cardio-cerebrovascular diseases, cardio-cerebrovascular diseases-related death, or all-cause death according to the TyG index quartile.

Total Men Women
The primary outcomes (Cardio-cerebrovascular diseases and all-cause mortality) Q1 Reference Reference
Q2 1.062 (0.981−1.150) 1.099 (0.986−1.226)
Q3 1.110 (1.024−1.204) 1.046 (0.938−1.166)
Q4 1.151 (1.058−1.252) 1.063 (0.954−1.184)
Subgroups Men Women
Cardiovascular diseases Q1 Reference Reference
Q2 1.114 (0.969−1.282) 1.238 (1.017−1.508)
Q3 1.185 (1.031−1.363) 1.183 (0.971−1.440)
Q4 1.232 (1.068−1.422) 1.238 (1.018−1.505)
Ischemic cerebrovascular diseases Q1 Reference Reference
Q2 1.005 (0.850−1.187) 1.040 (0.821−1.316)
Q3 1.225 (1.041−1.441) 1.226 (0.981−1.532)
Q4 1.232 (1.039−1.460) 1.312 (1.054−1.634)
Hemorrhagic cerebrovascular diseases Q1 Reference Reference
Q2 1.126 (0.781−1.625) 0.972 (0.642−1.472)
Q3 0.937 (0.634−1.384) 0.554 (0.347−0.884)
Q4 0.905 (0.602−1.360) 0.452 (0.278−0.734)
Other cerebrovascular diseases Q1 Reference Reference
Q2 1.007 (0.833−1.218) 0.956 (0.789−1.160)
Q3 0.949 (0.780−1.155) 0.943 (0.778−1.143)
Q4 0.971 (0.793−1.189) 0.883 (0.727−1.073)
Cardio-cerebrovascular diseases- Q1 Reference Reference
related deaths Q2 1.231 (0.778−1.947) 0.908 (0.405−2.035)
Q3 1.157 (0.713−1.876) 1.452 (0.708−2.976)
Q4 1.167 (0.698−1.954) 1.242 (0.601−2.566)
All-cause deaths Q1 Reference Reference
Q2 1.048 (0.911−1.205) 1.216 (0.936−1.580)
Q3 1.105 (0.955−1.278) 1.009 (0.776−1.313)
Q4 1.063 (0.907−1.245) 0.990 (0.763−1.284)

Adjusted for age, smoking status (ever and never smokers), drinking status (rare, sometimes, and often) and physical activity (rare, sometimes, and regular), body mass index, systolic blood pressure, LDL-C, economic status (low, middle, and high), and anti-hypertensive medications.

Cerebrovascular diseases are as follows: ischemic cerebrovascular diseases, I63 (cerebral infarction), I65 (occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction), and I66 (occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction); hemorrhagic cerebrovascular diseases, I60 (subarachnoid hemorrhage), I61 (intracranial hemorrhage), and I62 (other nontraumatic intracranial hemorrhage); and other cerebrovascular diseases, I64 (stroke, not specified as hemorrhage or infarction), I67 (other cerebrovascular diseases), I68 (cerebrovascular disorders in diseases classified elsewhere), and I69 (sequelae of cerebrovascular disease).