Baygin 2011.

Methods	RCT Parallel design
Participants	Location: Turkey Children needing primary molar tooth extraction, N = 45, age range 6 to 12 years Setting: paediatric dental clinic Group 1: 10 male, 5 female; mean age (years) 8.53 (standard deviation (SD) 1.60) Group 2: 8 male, 7 female; mean age (years) 9.33 (SD 1.4) Group 3: 7 male, 8 female; mean age (years) 9.33 (SD 2.2)
Interventions	Group 1: 100 mg/5 mL ibuprofen 30 minutes preoperatively by age (N = 15) Group 2: 250 mg/4 mL paracetamol 1 hour preoperatively by age (N = 5) Group 3: placebo 1 hour preoperatively (N = 15) All oral
Outcomes	5 face scale (15 minutes, 1, 2, 3, 4, 5, 6 and 24 hours)
Notes	It was difficult to determine the actual dosage of painkillers given. The trial authors stated in the discussion that ibuprofen varied from 4 to 10 mg/kg body weight and paracetamol from 7 to 15 mg/kg
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Participants selected a number; an independent person had previously numbered and anonymised containers
Allocation concealment (selection bias)	Unclear risk	See above. The independent person then allocated drugs in lightproof anonymised containers that contained the premeasured volume. It is unclear how the participants were instructed regarding the time at which they took the solution and also the amount of the solution if they were blind to the drug they were taking. We sent an email to the trial authors for clarification
Blinding (performance bias and detection bias) All outcomes	Low risk	Quote: "double‐blind" Participant and operator were blind to the intervention
Incomplete outcome data (attrition bias) All outcomes	Low risk	The trial authors evaluated all included participants
Selective reporting (reporting bias)	Low risk	The trial authors reported all expected outcomes
Other bias	Low risk	None apparent