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. 2021 Nov 3;6(4):e960. doi: 10.1097/PR9.0000000000000960

Figure 4.

Figure 4.

Characteristics of the differentially methylated positions (DMPs) between healthy controls and LBP participants*. Representation of (A) the hypermethylated and hypomethylated DMPs, (B) the genomic distribution, and (C) the neighborhood context of the DMPs detected in LBP participants compared with controls. Venn diagrams representing (D) the common differentially methylated genes between women and men in our study and (E) the overlap between our data and other studies on rat T cells (Massart et al), human pain genes (Meloto et al.), and rodent pain-related genes (Ultsh et al). For overlaps, pain, stress, and epigenetic-related genes mentioned in the text were highlighted in blue, red, and green, respectively. Significance of overlap between 2 groups was determined using the hypergeometric test. *LBP, low back pain.