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. 2021 Mar 22;4(2):e092. doi: 10.1097/OI9.0000000000000092

Table 2.

Animal studies which showed no effect on bone healing with the use of NSAIDs.

Drug classification NSAIDs Duration References
Acetic acid derivatives Indomethacin Elves et al (1982)[35]
Sudmann et al (1982)[36]
Boiskin et al (1988)[37]
Mbugua et al (1989)[38]
Keller et al (1990)[39]
Brown et al (2004)[40]
Ketorolac Long duration Mullis et al (2006)[41]
Ketorolac Short duration Fracon et al (2010)[42]
Diclofenac Long duration Tiseo et al (2006)[43]
Enolic acid derivatives Meloxicam Long duration Van de Heide et al (2008)[44]
Propionic acid derivatives Ibuprofen Long duration Tornkvist et al (1980)[45]
Huo et al (1991)[46]
Mullis et al (2006)[41]
Ketoprophen Long duration Urrutia et al (2007)[47]
Van de Heide et al (2008)[44]
Selective COX-2 inhibitors Celecoxib Long duration Brown et al (2004)[40]
Mullis et al (2006)[41]
Rofecoxib Long duration Mullis et al (2006)[41]
Tiseo et al (2006)[43]
Hak et al (2011)[48]
Etoricoxib Short duration Fracon et al (2010)[42]
Sulfonanilides Nimesulide Short duration Teofilo et al (2011)[49]

COX-2 = cyclooxygenase-2.