Table 3.
Association results of 3 SNPs with the presence and degree of BHR.
| PC20; categorical | PC20; continuous | BHR† | ||||||||||
| SNP | Risk allele | <1 | 1–4 | 4–16 | >16 | P value | β | SE | P value | aOR (95% CI) | P value | |
| Number of cases | 79 | 160 | 197 | 240 | <.001 | −12.408 | 2.695 | <.001 | 3.599 (2.089–6.200) | <.001 | ||
| Proportion | 0.12 | 0.24 | 0.29 | 0.36 | ||||||||
| rs41355746 | C | Number of cases | 80 | 160 | 198 | 251 | .005 | −9.958 | 2.926 | .001 | 2.704 (1.532–4.775) | .001 |
| Proportion | 0.12 | 0.23 | 0.29 | 0.36 | ||||||||
| rs41441651 | C | Number of cases | 80 | 160 | 197 | 250 | .004 | −9.284 | 2.882 | .001 | 2.657 (1.520–4.645) | .001 |
| Proportion | 0.12 | 0.23 | 0.29 | 0.36 | ||||||||
Regression analyses were adjusted for age and sex.
β = β estimate; aOR = adjusted odds ratio; BHR = bronchial hyperresponsiveness; CI = confidence interval; PC20 = provocative concentration of methacholine inducing a 20% decrease in forced expiratory volume in 1 s; SE = standard errors; SNP = single nucleotide polymorphism.
†
BHR was defined as a decrease in forced expiratory volume in 1 s of ≥20% with inhalation of <16 mg/mL methacholine.