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Potential drugs targeting MANF.
| Drug | Subject | Target | Mechanism |
|---|---|---|---|
| Valproic acid | Rat | Brain | mRNA and protein expression of MANF increased |
| Piperine [89] | Mouse and PC12 cell | Brain | Antagonize ER stress by activating MANF expression |
| Paroxetine [90] | Primary astrocytes | Increasing mRNA expression of MANF | |
| Metformin [91] | Human | Serum | Elevating serum MANF levels in PCOS women |
| Liraglutide [82] | Human | Serum | Upregulating MANF |
