Table 1.
IC50 values of the MTT assayed compounds against the tested cell lines.
| Comp. | Structure | MCF-7 | HepG-2 | HCT-116 | WI-38 |
|---|---|---|---|---|---|
| 5 |
|
4.66 | 3.29 | 1.60 | 61.39 |
| 6 |
|
18.32 | 15.45 | 16.40 | 117.36 |
| 7a |
|
1.37 | 1.05 | 1.46 | 60.8 |
| 7b |
|
1.25 | 2.12 | 2.54 | 82.17 |
| 7c |
|
11.79 | 19.41 | 15.34 | 136.51 |
| 7d |
|
23.11 | 29.14 | 31.47 | 143.82 |
| 7e |
|
13.38 | 22.41 | 17.80 | 142.63 |
| 7f |
|
20.46 | 31.45 | 18.30 | 157.19 |
| 7 g |
|
42.10 | 26.55 | 31.70 | 131.54 |
| 7 h |
|
19.20 | 14.90 | 22.70 | 95.14 |
| 7i |
|
16.15 | 15.22 | 18.40 | 103.26 |
| 7j |
|
16.80 | 14.08 | 15.10 | 84.92 |
| 7 k |
|
17.14 | 20.05 | 18.70 | 75.31 |
| 7 l |
|
3.50 | 2.64 | 2.75 | 68.21 |
| 10 |
|
3.55 | 3.16 | 5.49 | 78.42 |
| 11a |
|
12.31 | 15.47 | 17.16 | 85.13 |
| 11b |
|
15.54 | 17.62 | 13.44 | 72.28 |
| 11c |
|
6.29 | 7.31 | 5.72 | 52.31 |
| 11d |
|
4.15 | 2.23 | 1.94 | 50.28 |
| 11e |
|
18.22 | 23.91 | 14.52 | 80.06 |
| 11f |
|
6.15 | 7.05 | 3.47 | 62.37 |
| 11 g |
|
5.73 | 6.42 | 4.80 | 70.14 |
| 11 h |
|
20.17 | 31.12 | 34.9 | 103.22 |
| 18a |
|
5.81 | 8.29 | 5.13 | 123.42 |
| 18b |
|
2.67 | 6.11 | 4.19 | 64.35 |
| 18c |
|
19.37 | 8.59 | 21.72 | 92.11 |
| Sorafenib | — | 4.32 | 3.76 | 5.28 | — |