Table 5.
Binary variable meta-analysis results.
Effect index | Detail index | Study | Heterogeneity test | Model | RR (95% CI) |
---|---|---|---|---|---|
Adverse reactions | Vomiting | 3 [16, 22, 27] | I 2 = 0%, P=0.90 | Fixed effects model | 0.83 (0.46, 1.51), P=0.55 |
Stress ulcer | 2 [22, 30] | I 2 = 14%, P=0.28 | Fixed effects model | 0.47 (0.22, 1.02), P=0.06 | |
Esophageal reflux | 8 [11, 13, 16, 17, 22, 28, 29, 31] | I 2 = 29%, P=0.19 | Fixed effects model | 0.43 (0.25, 0.74), P=0.002 | |
Bloating | 10 [11, 13, 17, 22, 27, 29, 31, 33] | I 2 = 0%, P=0.45 | Fixed effects model | 0.39 (0.26, 0.58), P < 0.00001 | |
Constipation | 12 [11, 13, 16, 19, 23, 27, 29, 33] | I 2 = 0%, P=0.76 | Fixed effects model | 0.31 (0.21, 0.45), P < 0.00001 | |
Diarrhea | 14 [11, 13, 16, 19, 22, 23, 27, 29, 31] | I 2 = 0%, P=0.93 | Fixed effects model | 0.22 (0.14, 0.34), P < 0.00001 | |
Gastric retention | 4 [11, 13, 27–29] | I 2 = 0%, P=0.84 | Fixed effects model | 0.34 (0.19, 0.60), P=0.0002 | |
Gastrointestinal bleeding | 10 [13, 15, 17, 19, 25, 26, 28, 29, 31] | I 2 = 0%, P=0.93 | Fixed effects model | 0.39 (0.28, 0.54), P < 0.00001 | |
| |||||
Complication rate | Lung infection | 12 [11, 13, 15, 17, 25, 26, 28–32] | I 2 = 65%, P=0.0009 | Random effects model | 0.44 (0.27, 0.72), P=0.001 |
Gastrointestinal infection | 4 [11, 13, 17, 29] | I 2 = 0%, P=0.96 | Fixed effects model | 0.40 (0.23, 0.68), P=0.0008 | |
Urinary tract infection | 6 [11, 13, 15, 17, 28, 29] | I 2 = 0%, P=0.93 | Fixed effects model | 0.27 (0.15, 0.49), P < 0.0001 | |
| |||||
Poor prognostic indicators | Mortality rate | 4 [16, 17, 22, 29] | I 2 = 0%, P=0.44 | Fixed effects model | 0.45 (0.22, 0.93), P=0.03 |
Bacterial imbalance rate | 6 [11, 15, 25, 26, 28, 32] | I 2 = 0%, P=0.79 | Fixed effects model | 0.32 (0.21, 0.48), P < 0.0001 |