Table 1.

Mechanisms of coronavirus disease 2019 liver injury

Mechanisms	Pathophysiology
Direct cytotoxicity	Active replication of SARS-CoV-2 in hepatic cells
Hyper-inflammatory reaction	Cytokine storm and activation of immune system
Systemic hypoxia	COVID-19 cardiomyopathy
Drug-induced liver injury	Liver toxicity to medication used to treat COVID-19

SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2; COVID-19: Coronavirus disease 2019.