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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Arthritis Rheumatol. 2021 Sep 26;73(11):2096–2104. doi: 10.1002/art.41779

Table 1. Association of polygenic scores for fasting insulin with serum urate concentrations and odds of gout in the UK Biobank (one-sample analysis).

All models were adjusted for age and sex as well as ten principal components and the genotyping platform used.

Change in urate (mg/dl) per SD in fasting insulin score (95% CI) P Odds ratio for gout per SD in fasting insulin score (95% CI) P
Unadjusted for BMI
All SNPs 0.023 (0.019 to 0.026) 6.3×10−33 1.03 (1.01 to 1.05) 9.5×10−4
Excluding outliers 0.031 (0.027 to 0.035) 8.2×10−61 1.05 (1.03 to 1.07) 1.0×10−7
Adjusted for BMI
All SNPs 0.031 (0.028 to 0.034) 1.8×10−69 1.05 (1.03 to 1.07) 8.8×10−7
Excluding outliers 0.040 (0.036 to 0.043) 8.6×10−114 1.07 (1.05 to 1.09) 9.8×10−13