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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2021 Sep 8;30(11):2079–2087. doi: 10.1158/1055-9965.EPI-21-0400

Table 1.

CpG sites with genetically predicted DNA methylation to be independently associated with pancreatic cancer risk after adjustment for previously identified risk SNPs

CpG site Chr Position (build37) Number of SNPs used for prediction Classification R2a OR (95% CI)b P valuec P value after FDR Risk SNP adjusted for P value after adjusting for risk SNP
cg20930114 2 110372285 15 exonic 0.02 1.94 (1.44–2.61) 1.28 × 10−5 0.019 rs1486134 1.28 × 10−5
cg01554064 9 106855171 27 upstream 0.20 1.22 (1.12–1.32) 1.75 × 10−6 0.003 rs505922 1.77 × 10−6
cg02871659 16 2014063 7 intronic 0.32 1.18 (1.09–1.28) 3.34 × 10−5 0.045 rs7190458 3.41 × 10−5
cg18279742 16 2015703 46 upstream/downstream 0.21 1.20 (1.10–1.30) 2.89 × 10−5 0.040 rs7190458 2.94 × 10−5
cg15445000 17 37608096 50 upstream 0.28 0.85 (0.80–0.91) 2.42 × 10−6 0.005 rs4795218 1.16 × 10−6
cg03013999 17 37608204 21 upstream 0.18 0.81 (0.74–0.89) 4.02 × 10−6 0.007 rs4795218 1.63 × 10−6
cg19439043 17 37719913 27 intergenic 0.04 0.64 (0.53–0.76) 6.76 × 10−7 0.002 rs4795218 2.51 × 10−7
cg17288560 17 37720009 18 intergenic 0.05 0.62 (0.52–0.75) 3.41 × 10−7 0.001 rs4795218 1.35 × 10−7
cg24520381 17 37784694 20 intronic 0.02 0.54 (0.43–0.69) 3.71 × 10−7 0.001 rs4795218 1.10 × 10−7
cg24483576 17 37792770 13 UTR3 0.03 0.51 (0.38–0.68) 7.31 × 10−6 0.012 rs4795218 4.23 × 10−6
cg19586165 17 37814072 10 exonic 0.08 1.38 (1.19–1.59) 1.26 × 10−5 0.019 rs4795218 2.86 × 10−6
cg02944084 17 37827057 22 downstream 0.03 1.81 (1.44–2.29) 5.82 × 10−7 0.001 rs4795218 1.47 × 10−7
cg16557858 17 37879740 23 intronic 0.06 1.47 (1.25–1.74) 4.98 × 10−6 0.009 rs4795218 1.23 × 10−6
cg22833065 17 38095691 14 intergenic 0.03 0.59 (0.46–0.76) 3.14 × 10−5 0.043 rs4795218 1.86 × 10−5
cg04520704 22 18325160 18 intronic 0.08 1.36 (1.18–1.57) 2.63 × 10−5 0.038 rs16986825 2.65 × 10−5
a

R2: model prediction performance (R2) derived using FHS data

b

OR (odds ratio) and CI (confidence interval) per one standard deviation increase in genetically predicted DNA methylation

c

P value: derived from association analyses of 8,282 cases and 6,728 controls; FDR-adjust p≤0.05 considered statistically significant