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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2021 Sep 8;30(11):2079–2087. doi: 10.1158/1055-9965.EPI-21-0400

Table 2.

CpG sites with genetically predicted DNA methylation to be associated with pancreatic cancer risk that are potentially influenced by previously identified risk SNPs

CpG site Chr Position (build37) Number of SNPs used for prediction Classification R2b OR (95% CI)c P valued P value after FDR Risk SNP adjusted for P value after adjusting for risk SNP
cg10015974 1 199827580 87 intergenic 0.13 0.80 (0.73–0.87) 1.28 × 10−7 3.84 × 10−4 rs16986825;
rs3790844		 0.02
cg10098523 1 200002343 40 intronic 0.22 0.83 (0.78–0.90) 1.29 × 10−6 2.73 × 10−3 rs16986825;
rs3790844		 0.52
cg07926895 1 200005833 24 intronic 0.03 0.61 (0.49–0.77) 1.89 × 10−5 2.77 × 10−2 rs16986825;
rs3790844		 0.32
cg17804356 1 200009927 3 intronic 0.01 3.38 (2.12–5.39) 2.81 × 10−7 8.05 × 10−4 rs16986825;
rs3790844		 0.32
cg07507801 5 1291235 5 intronic 0.03 2.29 (1.66–3.16) 5.14 × 10−7 1.30 × 10−3 rs2736098;
rs35226131;
rs401681		 0.13
cg07380026 5 1296007 14 upstream 0.01 4.52 (2.97–6.90) 2.39 × 10−12 1.67 × 10−8 rs2736098;
rs35226131;
rs401681		 4.55 × 10−3
cg26603275 5 1298965 10 intergenic 0.04 2.24 (1.75–2.87) 1.11 × 10−10 6.36 × 10−7 rs2736098;
rs35226131;
rs401681		 0.05
cg11624060 5 1316038 25 intergenic 0.18 1.28 (1.17–1.40) 2.49 × 10−8 9.23 × 10−5 rs2736098;
rs35226131;
rs401681		 0.93
cg26209169 5 1316264 22 intergenic 0.24 1.24 (1.15–1.34) 2.19 × 10−8 8.62 × 10−5 rs2736098;
rs35226131;
rs401681		 0.83
cg10441424 5 1316636 16 intergenic 0.01 2.08 (1.52–2.86) 5.82 × 10−6 1.02 × 10−2 rs2736098;
rs35226131;
rs401681		 0.65
cg07493874 5 1342172 11 intronic 0.15 0.69 (0.61–0.77) 8.91 × 10−11 5.61 × 10−7 rs2736098;
rs35226131;
rs401681		 0.93
cg19915256 5 1345677 11 upstream 0.02 2.85 (2.00–4.04) 5.16 × 10−9 2.32 × 10−5 rs2736098;
rs35226131;
rs401681		 0.52
cg27028750 5 1349422 20 intergenic 0.25 0.79 (0.74–0.85) 6.59 × 10−10 3.46 × 10−6 rs2736098;
rs35226131;
rs401681		 0.43
cg03474926 9 136023407 24 intronic 0.01 2.72 (1.90–3.89) 5.18 × 10−8 1.72 × 10−4 rs505922 0.36
cg01169778 9 136038690 14 intronic 0.04 1.98 (1.46–2.68) 1.04 × 10−5 1.62 × 10−2 rs505922 0.13
cg14653977 9 136038692 20 intronic 0.03 4.27 (3.09–5.89) 1.12 × 10−18 3.53 × 10−14 rs505922 0.08
cg13531387 9 136078657 13 intergenic 0.11 0.34 (0.25–0.45) 3.16 × 10−13 2.49 × 10−9 rs505922 0.75
cg00878953 9 136129875 36 downstream 0.15 0.65 (0.54–0.79) 6.83 × 10−6 1.16 × 10−2 rs505922 0.42
cg11879188 9 136149908 36 intronic 0.5 2.28 (1.84–2.83) 4.84 × 10−14 4.36 × 10−10 rs505922 0.89
cg21160290 9 136149941 43 intronic 0.71 1.99 (1.69–2.34) 8.87 × 10−17 1.12 × 10−12 rs505922 0.76
cg22535403 9 136150032 44 intronic 0.69 2.29 (1.89–2.77) 4.63 × 10−17 7.29 × 10−13 rs505922 0.59
cg24267699 9 136151359 13 upstream 0.59 2.50 (2.07–3.02) 1.33 × 10−21 8.38 × 10−17 rs505922 0.01
cg06818865 9 136151958 10 intergenic 0.3 1.84 (1.52–2.24) 8.47 × 10−10 4.10 × 10−6 rs505922 0.16
cg13660174 9 136238392 19 intronic 0.07 1.64 (1.34–2.00) 1.30 × 10−6 2.73 × 10−3 rs505922 0.29
cg13568213 9 136387235 16 intronic 0.03 7.05 (3.43–14.48) 1.08 × 10−7 3.40 × 10−4 rs505922 0.17
cg21101465 13 28493404 20 upstream 0.04 0.61 (0.49–0.76) 9.94 × 10−6 1..61 × 10−2 rs9581943 0.06
cg11853320 13 28493913 52 upstream 0.08 0.69 (0.61–0.79) 3.88 × 10−8 1.36 × 10−4 rs9581943 0.46
cg26793256 13 28494004 55 upstream 0.06 0.72 (0.62–0.82) 1.56 × 10−6 3.17 × 10−3 rs9581943 0.16
cg04633225 13 28494161 22 upstream 0.02 0.45 (0.34–0.59) 1.09 × 10−8 4.58 × 10−5 rs9581943 0.06
cg11213248 13 28534648 7 intergenic 0.22 0.81 (0.75–0.88) 1.16 × 10−6 2.61 × 10−3 rs9581943 2.00 × 10−4
a

R2: model prediction performance (R2) derived using FHS data

b

OR (odds ratio) and CI (confidence interval) per one standard deviation increase in genetically predicted DNA methylation

c

P value: derived from association analyses of 8,282 cases and 6,728 controls; FDR-adjust p≤0.05 considered statistically significant