Table 3.

Eight-year risk of incident arterial stiffening for greater baseline leptin levels

	Risk of AS (Dependent variable) OR (95% CI)	P value
Leptin[+] vs. Leptin[−]a (Independent variable)
Unadjusted	2.22 (1.10–4.45)	0.025
Multivariable Model ab	2.50 (1.11–5.64)	0.028
Multivariable Model bc	2.45 (1.07–5.63)	0.035
Multivariable Model cd	3.02 (1.40–6.51)	0.005
Multivariable Model de	2.92 (1.32–6.43)	0.008

AS arterial stiffening, OR odds ratio

^aBaseline LPT[+] (Leptin > 2.97 ng/mL) vs. baseline LPT[−] (Leptin < 2.97 ng/mL)

^bAdjusted for baseline age, pulse pressure (rank), body weight, renal function (log-transformed eGFR), smoke, physical activity, and alcohol consumption

^cAdjusted for Model a plus Insulin resistance and hypolipidemic therapy at baseline (n = 440)

^dAdjusted for Model a plus body weight changes over time instead of body weight at baseline

^eAdjusted for Model b plus body weight changes over time instead of body weight at baseline (n = 440)