. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 May 5;6(11):1063–1070. doi: 10.1016/j.bpsc.2021.04.016

Table 3:

Overlapping DMRs identified in the PTSD vs Non-Traumatized Control group in both cohorts.

	Gene	Chr	p-value Dutch Cohort	FWER Dutch Cohort	p-value USA Cohort	p-value Fisher’s method	Direction
PTSD Youth vs. NTC Youth	TNXB	6	< 0.001	0.030	0.00033	0.02334^**	PTSD > NTC
	PM20D1	1	< 0.001	0.040	6.58E-05	0.01104^**	NTC > PTSD
	TNXB	6	< 0.001	0.100	0.00169	0.0992	PTSD > NTC
	DUSP22	6	< 0.001	0.320	0.00119	0.13888	NTC > PTSD
	GDF7	2	0.002	0.958	0.00119	0.415772	NTC > PTSD
	SLC1A4	2	0.004	0.990	0.00550	0.99	NTC > PTSD
	KLHL35	11	0.004	0.998	0.00018	0.596804	PTSD > NTC
	ZNF714	19	0.009	1	0.00206	0.996	NTC > PTSD
	OLFM3	1	0.016	1	0.02906	1	PTSD > NTC

Detected DMRs (L>2) using minfi’s “bumphunter” function; comparison based on the top 1000 hits in both cohorts. All findings met threshold of a combined FWER calculated with Fisher’s method of < 0.05.

^**

indicates a significant result in both cohorts. DMR = Differently methylated regions, Chr = Chromosome; PTSD = Post-Traumatic Stress Disorder; NTC = Non-Traumatized Control; FWER = Family-Wise Error Rate.