Table 4:
Significant post-hoc partial correlation results comparing peak methylation on DMPs/DMRs with regional grey matter volume estimates
| Gene | Chr | Region |
r Dutch Cohort |
p-value Dutch Cohort |
FDR p-value Dutch Cohort |
r USA Cohort |
p-value USA Cohort |
FDR p-value USA Cohort |
|
|---|---|---|---|---|---|---|---|---|---|
| PTSD Youth and NTC Youth | CRHBP | 5 | R Fusiform Gyrus | 0.328 | 0.002 | 0.018 | - | - | |
| CRHBP | 5 | L Fusiform Gyrus | 0.350 | < 0.001 | 0.016 | - | - | ||
| GDF7 | 2 | R Anterior Hippocampus | 0.288 | 0.006 | 0.037 | - | - | ||
| GDF7 | 2 | R vmPFC | 0.294 | 0.005 | 0.037 | - | - | ||
| GDF7 | 2 | R Fusiform Gyrus | - | - | - | 0.455 | < 0.001 | 0.003 | |
| GDF7 | 2 | L Fusiform Gyrus | - | - | - | 0.375 | 0.003 | 0.018 | |
| OLFM3 | 1 | R Anterior Hippocampus | −0.323 | 0.002 | 0.018** | −0.453 | < 0.001 | 0.003** | |
| OLFM3 | 1 | R vmPFC | −0.369 | < 0.001 | 0.014 | - | - | - | |
| PM20D1 | 1 | R Fusiform Gyrus | - | - | - | 0.384 | 0.003 | 0.017 | |
| SLC1A4 | 2 | R Fusiform Gyrus | - | - | - | 0.511 | < 0.001 | 0.001 | |
| SLC1A4 | 2 | L Fusiform Gyrus | - | - | - | 0.335 | 0.010 | 0.043 | |
| TNXB | 6 | R Anterior Hippocampus | - | - | - | −0.406 | 0.001 | 0.012 |
Partial correlations were controlled for age and sex of participant. All findings met threshold of FDR p-value < 0.05.
**
indicates a significant result in both cohorts; Chr = Chromosome; DMR = Differently methylated regions; DMP =Differently methylated position; PTSD = Post-Traumatic Stress Disorder; NTC = Non-Traumatized Control; vmPFC = ventromedial prefrontal cortex