Table 2.
Subgroup analyses of summary effect sizes by median year of enrolment, geographical region of study, day of mortality ascertainment and income classification of country
| Sepsis/shock |
Mortality |
|||||
|---|---|---|---|---|---|---|
| studies, n (patients, n) | OR (95% CI) | I 2 (%) | studies, n (patients, n) | OR (95% CI) | I 2 (%) | |
| Overall | 7 (1230) | 1.51 (1.09–2.09) | 0 | 31 (4383) | 2.10 (1.58–2.79) | 60.6 |
| By median year of enrolment | ||||||
| 1999–2009 | 4 (802) | 1.81 (1.17–2.79) | 0 | 21 (3228) | 1.94 (1.44–2.62) | 57.9 |
| 2010–17 | 3 (428) | 1.19 (0.58–2.47) | 36.7 | 10 (1155) | 2.75 (1.36–5.55) | 64.4 |
| By geographical region | ||||||
| Asia | 6 (1181) | 1.44 (1.03–2.02) | 93.3 | 19 (2872) | 2.68 (1.82–3.93) | 62.2 |
| Europe | 0 | — | — | 4 (532) | 1.25 (0.73–2.13) | 17.5 |
| America | 1 (49) | — | — | 7 (887) | 1.60 (1.08–2.39) | 38.7 |
| Africa | 0 | — | — | 1 (92) | — | — |
| By mortality day from infection onset | ||||||
| Day 14 | — | — | — | 3 (421) | 2.09 (0.67–6.50) | 72.2 |
| Day 28 to 30 | — | — | — | 15 (2756) | 2.47 (1.58–3.85) | 69.1 |
| By income classification of country | ||||||
| high | 2 (555) | — | — | 18 (2574) | 2.12 (1.38–3.25) | 71.5 |
| middle | 5 (675) | 1.46 (0.92–2.32) | 71.7 | 13 (1809) | 2.07 (1.51–2.84) | 26.9 |
Bolded values indicate statistical significance.