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. 2021 Nov 4;12:6393. doi: 10.1038/s41467-021-26744-4

Fig. 7. Hepatic gene transfer provides superior bioavailability of GAA in refractory tissues compared to enzyme replacement therapy (ERT).

Fig. 7

A Representation of GAA kinetics in heart measured by quantification of lysosomal GAA enzyme over time by Western blot. B Analysis of the area under the curve (AUC) between time 0 (day −1) and week 18 in heart (ERT, n = 4; AAV-GAA, n = 4). C Representation of GAA kinetics in quadriceps (ERT, n = 4; AAV-GAA, n = 5). D Analysis of the area under the curve (AUC) in quadriceps. Data shown as average ± SD. Statistical analysis: t-test; n.s. non-significant.