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. 2021 Nov 4;12:6393. doi: 10.1038/s41467-021-26744-4

Fig. 9. SPK-3006 drives vector dose-dependent expression of GAA in liver and tissue uptake in non-human primates.

Fig. 9

A Circulating GAA antigen levels 4 weeks of post-injection of C57BL/6 mice with AAV-GAA or SPK-3006 at 2 × 1012 vg/kg (n = 5 per group). B GAA activity in plasma of non-human primates treated with SPK-3006 (n = 4 per group). C, E Western blot analysis of GAA antigen levels in spinal cord (C) and brain (E). D, F Quantification of lysosomal GAA antigen in spinal cord (D) and brain (F) (2 × 1012 and 6 × 1012 vg/kg, n = 4 per group; 2 × 1013, n = 3). Data shown as average ± SD. Statistical analysis: A Two-sided Mann–Whitney t-test; B Two-way ANOVA with Tukey post-hoc test; D, F One-way ANOVA.