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. 2021 Nov 4;12:6373. doi: 10.1038/s41467-021-26704-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Simulated FCD from a mean-field model (MFM) optimized using the same algorithm as pMFM, but with model parameters constrained to be the same across cortical regions. B Agreement between empirically observed and simulated static FC from MFM optimized using the same algorithm as pMFM, but with model parameters constrained to be the same across cortical regions. C Agreement (Pearson’s correlation) between simulated and empirically observed static FC, as well as disagreement (KS distance) between simulated and empirically observed FCD across different conditions in the test set. Each boxplot comprises 10 correlation values (left) or 10 KS statistic (right) based on the 10 best candidate sets from the validation set. The boxes show the inter-quartile range (IQR) and the median. Whiskers indicate 1.5 IQR. Black crosses represent outliers. The pMFM utilizing both anatomical and functional gradients (FC gradient and T1w/T2w spatial maps) performed the best, suggesting that T1w/T2w and FC gradient provided complementary contributions. * indicates statistical significance after correcting for multiple comparisons with a false discovery rate (FDR) of q < 0.05. All p values are reported in Supplementary Table S1. Source data are provided as a Source Data file.