Fig. 6. LDMC with DOX improves tumor vessel normalization in the WT but not Redd1^−/− mice.

a Representative images of α-SMA⁺ smooth muscle cell coverage on CD31⁺ tumor vessels in B16F1 tumors. Scale bar, 50 μm. b Quantification of α-SMA⁺ smooth muscle cell coverage (n = 10). c Representative images of NG2⁺ pericyte coverage on CD31⁺ tumor vessels. Scale bar, 50 μm. d Quantification of NG2⁺ pericyte coverage (n = 10). e Representative images of tumor sections showing FITC-dextran leakage, CD31⁺ blood vessels, and DAPI-stained nuclei. Scale bar, 50 μm. f Quantification of FITC-dextran leakage (n = 10). g Representative images of tumor sections showing the hypoxyprobe⁺ area and CD31⁺ blood vessels. Scale bar, 50 μm. h Quantification of hypoxyprobe⁺ area (n = 10). Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.