Table 2.
Hazard ratios for diabetes by number of cumulative days antibiotics prescribed.
| Antibiotics non-user | Number of cumulative days antibiotics prescribed | p for trend | |||
|---|---|---|---|---|---|
| 1–29 | 30–89 | ≥ 90 | |||
| Events, N | 1586 | 7047 | 3989 | 1144 | |
| Person-years, 104 | 23 | 103 | 53 | 13 | |
| aHR (95% CI) | |||||
| Model 1 | 1.00 (ref.) | 1.00 (0.94 1.05) | 1.07 (1.01 1.13) | 1.20 (1.11 1.30) | < 0.001 |
| Model 2 | 1.00 (ref.) | 1.01 (0.96 1.07) | 1.09 (1.03 1.16) | 1.24 (1.15 1.34) | < 0.001 |
| Model 3 | 1.00 (ref.) | 0.98 (0.93 1.04) | 1.04 (0.97 1.11) | 1.16 (1.07 1.26) | < 0.001 |
| aHR (95% CI) | |||||
| Model 1 | 1.01 (0.95 1.06) | 1.00 (ref.) | 1.07 (1.03 1.11) | 1.21 (1.13 1.29) | < 0.001 |
| Model 2 | 0.99 (0.94 1.05) | 1.00 (ref.) | 1.08 (1.04 1.13) | 1.23 (1.16 1.31) | < 0.001 |
| Model 3 | 1.02 (0.96 1.08) | 1.00 (ref.) | 1.06 (1.02 1.10) | 1.18 (1.11 1.26) | < 0.001 |
aHR adjusted hazard ratio, CI confidence interval, ref. reference.
Model 1 Adjusted for age, sex, and body mass index.
Model 2 Adjusted for Model 1 plus smoking status, days with alcohol drinking per week, physical activity, household income, and residence.
Model 3 Adjusted for Model 2 plus family history of diabetes, Charlson comorbidity index, fasting blood sugar, total cholesterol, and acid suppressants use.