Table 2.

Level and activity of c-proteasomes in human plasma.

First author	Year	Disease	Disease in detail	N	Plasma proteasome concentration (ng/mL)	Chymotrypsin-like activity	Ref
Lavabre-Bertranda	2001	Healthy		73	2356	N/A	42
		Hemopoietic malignancies	Solid tumor	20	7589
			Myeloproliferative disorder	37	4099
			Myelodysplastic syndromes	19	2922
Stoebnerb	2005	Healthy		14	1957	N/A	44
		Metastatic malignant melanoma	Stage I/II	13	2515
			Stage III	6	3725
			Stage IV	10	8554
			Severe psoriasis	13	2981
			Chronic idiopathic urticaria	6	3190
Henryb	2009	Healthy		40	2302	N/A	45
		Liver cirrhosis	with hepatocellular carcinoma (HCC)	50	3737
			without HCC	33	1808
Henryb	2013	Metastatic melanoma	Stage I/II	53	184	N/A	46
			Stage III	41	228
			Stage IV	27	499
Mab	2008	Healthy		40	N/A	0.80 pmol/s/mL	47
		Chronic lymphocytic leukemia		225	N/A	1.84 pmol/s/mL
Mab	2009	Healthy		97	N/A	0.8 pmol/s/mL	48
		Acute myeloid leukemia		174	N/A	2.0 pmol/s/mL
		Myelodysplastic syndrome		52	N/A	1.4 pmol/s/mL
Majetschakb	2010	Healthy		40	195	N/A	54
		Burn	Day 0	50	673
			Day 30	40	116.5
Heubnerb	2011	Healthy		55	290	N/A	55
		Epithelial ovarian cancer	Patient	120	595
			Patient, after therapy	68	457.5
Hoffmannb	2011	Healthy		50	305	N/A	56
		Nonmetastasized breast cancer		224	397.5
Fukasawab	2015	Healthy		76	1,340	N/A	57
		Hemodialysis patient		76	1.381
Manasanchb	2017	Multiple myeloma	Patient	45	N/A	0.83 pmol/s/ml	58
			After carfilzomib treatment		N/A	0.23 pmol/s/ml
Oldziejb	2014	Healthy		30	2010	1.02 U/mg	59
		Multiple myeloma		64	4380	1.32 U/mg

^aThe values are presented as the mean.

^bThe values are presented as the median.