Fig. 1. α5SNP expression and COPD-like remodeling in human airway epithelium.

a Scheme highlighting the experimental systems (created with BioRender.com). Inflammation of the lamina propria (b), and epithelial phenotypes (c) were quantified from 123 human nasal polyp samples on three micrographs by two histo-pathologists (bar = 100 µm, E = epithelium, C = chorion). Effect of genotype, age, gender and, allergy/asthma on human epithelial phenotype and inflammation was analyzed in multivariate regression analysis (Table 1).