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. 2021 Oct 11;53(10):1569–1579. doi: 10.1038/s12276-021-00684-x

Fig. 3. Prmt1-deficient aortas exhibit VSMC apoptosis and medial degeneration.

Fig. 3

a Histological analysis of thoracic aortas isolated from the f/f and smKO mice treated with tmx for 10 weeks. Representative images of hematoxylin and eosin (H&E) staining. Scale bar: 100 μm (upper), scale bar: 50 μm (bottom). Immunostaining for αSMA on the f/f and smKO aortas. Scale bar: 40 μm. b Representative confocal microscopic images of TUNEL-positive nuclei (red) in the f/f and smKO mouse aortas. Scale bar: 50 μm. c Quantification of TUNEL-positive nuclei in Panel b. Data represent the mean ± SD. ***P < 0.01, Student’s t-test. d Histological analysis of thoracic aortas isolated from the f/f and smKO mice treated with tmx for 20 weeks. Representative images of H&E, Verhoeff-Van Gieson (VVG), and Masson’s trichrome (MT) staining. Scale bar: 100 μm. Immunostaining for αSMA in the f/f and smKO aortas. Scale bar: 40 μm.