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. 2021 Oct 11;53(10):1569–1579. doi: 10.1038/s12276-021-00684-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Heatmap of reactome database clusters demonstrating the expression pattern of genes with up- and downregulated expression between the f/f and smKO aortic samples. b The enrichment map highlighting the results of Gene Set Enrichment Analysis (GSEA) of RNA samples from the f/f and smKO aortas (n = 2). c Bar charts presenting the normalized enrichment score (NES) of The Human Phenotype Ontology data (Molecular Signatures Database v7.2, GSEA, Broad Institute). d GSEA enrichment plots showing representative gene sets of The Human Phenotype Ontology database.