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. 2021 Oct 11;53(10):1569–1579. doi: 10.1038/s12276-021-00684-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a–c Relative RNA expression levels of the contractile genes Myh11 (a), Acta2 (b) and Tagln (c) in the RVSMCs expressing a combination of shCon or shPrmt1 and myocardin. n = 3. Data represent the mean ± SEM. *P < 0.05, ***P < 0.001, Student’s t-test. d–g Chromatin immunoprecipitation (ChIP) assays of the shCon- or shPrmt1-expressing A7R5 cells for histone modification markers in the promoter regions of myocardin (+1 ~ -452) and SRF ( + 1 to −509) genes. Values are expressed as a percentile of input. n = 3. Data represent the mean ± SEM. NS: not significant, **P < 0.01, ***P < 0.001. Student’s t-test. h Working model summarizing the regulatory mechanism of myocardin expression and maintenance of vascular smooth muscle function by Prmt1-mediated histone modification.