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. 2021 Nov 4;12:6410. doi: 10.1038/s41467-021-26735-5

Fig. 4. Conformational changes of critical motifs near the agonist-binding pocket.

Fig. 4

a Different conformations of the E124-R283 salt bridge in the active structures of GHSR with ghrelin and ibutamoren and the inactive structure of GHSR with C12. The salt bridge interactions are shown as dashed lines. b Rearrangement of the aromatic cluster residues W276, F279, H280, and F312 in the active and inactive GHSR. Two active GHSR and the inactive GHSR structures are colored in blue, green, and purple, respectively. Ghrelin, ibutamoren, and C12 are shown as orange, yellow and lemon sticks, respectively.