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. 2021 Nov 4;11:21637. doi: 10.1038/s41598-021-01164-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic overview of the study; t1/t2: first part with acute 5-HTP challenge in cross-over design, all participants completed both conditions but at different time points; t3 and placebo condition from t1 or t2: second part with 4-week TRP enriched diet or placebo, every 40 participants completed one of the conditions (mixed between subject design); RMET: reading the mind in the eyes task.