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. 2021 Nov 4;11:21677. doi: 10.1038/s41598-021-00523-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of haeTKV to genetics and kidney function: HaeTKV values for different groups of genotypes. The first documented haeTKV value was used for each patient (a). eGFR and haeTKV show a loose inverse relation in the total cohort (b). Kaplan–Meier of kidney survival. The highest quartile of haeTKVmax18values shows poorest kidney outcome (c). Scatter plot and regression lines of eGFR values of haeTKVmax18 patients stratified according to haeTKVmax18 quartiles (d). Normalized yearly eGFR loss of haeTKVmax18 patients stratified according to haeTKVmax18 quartiles. Only patients with at least 3 visits spanning at least one year were used to obtain valid estimations (e).