Table 3.
Effect of 4-HI on neurotransmitters levels in ICH-treated rats.
| S. No. | Groups |
Neurotransmitters (ng/mg protein) |
|||
|---|---|---|---|---|---|
| GABA | Glutamate | Ach | Dopamine | ||
| 1. | Vehicle control | 125.0 ± 0.42 | 81.10 ± 0.43 | 7.22 ± 0.12 | 97.22 ± 0.42 |
| 2. | Sham control | 122.9 ± 0.48 | 80.71 ± 0.52 | 7.55 ± 0.17 | 98.18 ± 0.56 |
| 3. | 4-HI 100 Per se | 123.5 ± 0.45 | 80.26 ± 0.62 | 7.19 ± 0.19 | 95.95 ± 0.67 |
| 4. | ALB | 17.80 ± 0.74* | 160.9 ± 0.65* | 2.14 ± 0.14* | 31.37 ± 0.46* |
| 5 | ALB + 4-HI 50 | 32.42 ± 0.37@ | 137.0 ± 0.79@ | 3.60 ± 0.22@ | 52.56 ± 0.57@ |
| 6. | ALB + 4-HI 100 | 53.00 ± 1.56@# | 117.6 ± 0.60@# | 4.88 ± 0.22@# | 62.08 ± 0.45@# |
One-way ANOVA followed by (post-hoc Tukey’s test) was used,
*
p < 0.001 v/s vehicle control; sham control and 4-HI 100 Per se;
@
p < 0.001 v/s ALB;
@#
p < 0.001 v/s ALB + 4-HI 50 (n = 6).