FIGURE 5.

Cefazolin clinical dose and susceptibility breakpoint. The probability of attaining the exposure target with a given dose decrease with increase in the MIC of Mtb. The 7 days simulated PK profile with 100 mg/kg and 200 mg/kg dose is shown for children (A) <3 years-old, (C) 3–5 years-old, and (E) 12–15 years-old. The corresponding probability of target attainment, summated over the MIC in clinical strains of Mtb, in these three different age groups, for two different clinical doses administered as once or twice daily is shown in (B), (D), and (F). We proposed the cefazolin susceptibility breakpoint for Mtb as 1–2 mg/L.