TABLE 1.

Monte Carlo simulation model input and output for 10,000 children.

	In domain of input		Observed in 10,000 subject simulations
	Median parameter estimate	%CV	Median parameter estimate	%CV
Children <3 years (disseminated TB)
Clearance L/hr/kg	0.25	33.50	0.25	33.5
Intercompartmental clearance L/hr/kg	0.87	33.50	0.87	33.09
Central volume L/kg	0.31	31.80	0.31	31.66
Peripheral Volume L/kg	0.38	48.20	0.38	48.49
Children >3–5 years
Clearance L/hr/kg		33.5	0.23	33.36
Intercompartmental clearance L/hr/kg		36.6	0.81	33.56
Central volume L/kg		31.8	0.29	31.65
Peripheral Volume L/kg		48.2	0.35	49.05
Children teenagers
Clearance L/hr/kg	0.14	33.5	0.14	33.19
Intercompartmental clearance L/hr/kg	0.47	36.6	0.47	33.13
Central volume L/kg		31.8	0.17	31.66
Peripheral Volume L/kg		48.2	0.21	48.72