TABLE 3.
Comparison of the PK/PD parameters for cefazolin’s efficacy against M. tuberculosis.
| %TMIC EC50 | % TMIC H | AUC/MIC EC50 | AUC/MIC H | Cmax/MIC EC50 | Cmax/MIC H | |
|---|---|---|---|---|---|---|
| Mean | 38.9 | 7.53 | 96.2 | 0.731 | 24.4 | 0.718 |
| Standard Deviation | 2.98 | 1.72 | 58.6 | 0.262 | 18.6 | 0.458 |
| Standard Error of Mean | 1.22 | 0.703 | 23.9 | 0.107 | 7.59 | 0.187 |
| Lower 95% CI of mean | 35.8 | 5.72 | 34.7 | 0.456 | 4.87 | 0.238 |
| Upper 95% CI of mean | 42.0 | 9.34 | 158 | 1.01 | 43.9 | 1.20 |
| Coefficient of variation | 7.65% | 22.9% | 61.0% | 35.8% | 76.3% | 63.7% |
EC, effective concentration; H, Hill coefficient.