TABLE 4.
ADAPT pharmacokinetic-model generated parameters using concentrations provided by Cole (Cole and Pung, 1977). In the study by Cole (Cole and Pung, 1977) ,cefazolin 1 g was administered intravenously. After 60 min of drug administration in nine patients, the reported Cmax (mean ± Standard Deviation) was 65.65 + 29.65 mg/L in the serum and 12.45 + 5.75 mg/L in the pleural fluid (Cole and Pung, 1977).
| Serum estimate | % CV | Pleural estimate | % CV | |
|---|---|---|---|---|
| Total clearance [L/hr] | 1.441 | 64.9 | 1.469 | 85.03 |
| Central volume [L] | 1.525 | 89.26 | 1.71 | 102.88 |
| Intercompartmental clearance [L/hr] | 3.051 | 126.11 | 3.224 | 137.15 |
| Peripheral volume [L] | 3.368 | 105.08 | 2.696 | 125.06 |
| Half-life [hr] | 2.419 | 99.35 | 2.069 | 289.37 |
| Model-predicted versus observed concentration r 2 | 0.996 | 0.999 |