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. 2021 Nov 4;12:6380. doi: 10.1038/s41467-021-26629-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–c Zoom-in log₂ ratio contact map of chromosome 5 (0.1–0.4 Mb region; upper panel) and chromosome 13 (0.5–0.8 Mb region; lower panel) in CHD1-AID strain at G₁, S, and G₂ phases, respectively. The 1-kb resolution matrices of control and knockdown samples were used for log₂ ratio calculations. d Log₂ ratio of the average contact probability (CP) along genomic distance between control (Con.) and IAA-treated (+IAA) CHD1-AID strains at G₁, S, and G₂ phases. The gray shadow indicates the confidence interval around smooth (se). e, f Same as described for a but in ISW1-AID and CHD1ISW1-AID strains at G₁ phase. g Log₂ ratio of the average contact probability (CP) along genomic distance between control (Con.) and IAA-treated (+IAA) CHD1-AID, ISW1-AID, and CHD1ISW1-AID strains at G₁ phase. The gray shadow indicates the confidence interval around smooth. h Comparison of the short-versus-long range interaction (SVL) ratio per chromosome (n = 16) relative to 100 kb in CHD1-AID, ISW1-AID, and CHD1ISW1-AID strains at G₁ phase. The p-values were calculated using a one-sided Wilcoxon rank-sum test (*<0.05 and n.s. means not significant, the p-value of CHD1-AID; 0.041). Boxplot show median; box limits, upper and lower quartiles; whiskers.