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. 2021 Nov 4;11:21683. doi: 10.1038/s41598-021-01222-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Upper panel t-maps of the voxel-wise WM comparisons respectively between HC and MSA (a) and PD and MSA (b). Statistical threshold is set to p < 0.05 after FWE correction for multiple comparison. Lower panel box-plots of the WM density distribution in the significant cluster (from the comparison HC vs MSA) for each group, and results of the post-hoc t-tests on the regional values. *p < 0.05, **p < 0.01, ***p < 0.001.