Table 2.

ROC analysis results.

	T1w/T2w				T1w/T2w + Tissue density (GM or WM)
	AUC	p	Sensitivity	Specificity	AUC	p	Sensitivity	Specificity
MSA vs HC
L-Putamen	0.70	0.005	0.87	0.46	0.84	< 0.001	0.74	0.83
R-Putamen	0.71	0.003	0.91	0.50	0.88	< 0.001	0.78	0.87
Cerebellum GM	0.54	> 0.05	0.30	0.88	0.93	< 0.001	0.78	0.96
Brainstem WM	0.60	> 0.05	0.65	0.62	0.88	< 0.001	0.83	0.75
L-SN	0.72	< 0.001	0.61	0.77	0.88	< 0.001	0.96	0.71
R-SN	0.76	< 0.001	0.87	0.60	0.90	< 0.001	0.96	0.77
MSA vs PD
L-Putamen	0.67	0.019	0.52	0.81	0.78	< 0.001	0.57	0.92
R-Putamen	0.68	0.010	0.83	0.56	0.83	< 0.001	0.78	0.83
Cerebellum GM	0.57	> 0.05	0.48	0.56	0.85	< 0.001	0.74	0.98
Brainstem WM	0.59	> 0.05	0.52	0.65	0.81	< 0.001	0.61	0.90
L-SN	0.63	> 0.05	0.43	0.87	0.79	< 0.001	0.96	0.62
R-SN	0.64	> 0.05	0.26	0.94	0.80	< 0.001	0.65	0.90
MSA-P vs PD
L-Putamen	0.72	> 0.05	0.30	0.92	0.89	0.01	0.22	1
R-Putamen	0.66	> 0.05	0.57	0.63	0.93	< 0.001	0.26	1
Cerebellum GM	0.40	> 0.05	0.52	0.52	0.68	> 0.05	0.78	0.88
Brainstem WM	0.35	> 0.05	0.70	0.44	0.61	> 0.05	0.39	1
L-SN	0.62	> 0.05	0.57	0.81	0.78	> 0.05	0.48	0.94
R-SN	0.45	> 0.05	0.87	0.58	0.76	> 0.05	0.61	0.92
MSA-C vs PD
L-Putamen	0.50	> 0.05	0.52	0.75	0.59	> 0.05	0.83	0.58
R-Putamen	0.48	> 0.05	0.17	0.98	0.65	> 0.05	0.78	0.87
Cerebellum GM	0.68	> 0.05	0.13	0.92	0.92	< 0.001	0.57	1
Brainstem WM	0.76	0.018	0.26	0.88	0.93	< 0.001	0.48	1
L-SN	0.62	> 0.05	0.26	0.92	0.84	< 0.001	0.52	0.87
R-SN	0.66	> 0.05	0.22	0.96	0.84	< 0.001	0.52	0.94

ROC analysis results for patients’ discrimination. T1w/T2w regional values were used to discriminate between groups both alone and in combination with mean regional tissue density (GM/WM). Significant results were enhanced in bold.