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. 2021 Nov 4;11:21644. doi: 10.1038/s41598-021-00947-7

Figure 2.

Figure 2

The excitatory effect of l-lactate in POMC neurons depends only partially on lactate uptake. (A) The depolarization elicited by l-lactate was not abolished by the MCT inhibitor (300 µM 4-CIN). The resting membrane potential was − 55 mV. (B) Example of a POMC neuron excited by l-lactate (15 mM) that was also depolarized by the non-transportable isomer, d-lactate (15 mM). The resting membrane potential was − 54 mV. (C) The depolarization elicited by l-lactate was abolished by the MCT inhibitor (300 µM 4-CIN). The resting membrane potential was − 56 mV. (A1–C1) Summary of the effects of l-lactate, 4-CIN/l-lactate and d-lactate on the excitability of POMC neurons. Baselines are shown with the red dotted lines. Results represent the mean ± SD of ten different cells for recordings. **p < 0.01 one tailed test.