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. 2021 Oct 26;53(10):1623–1635. doi: 10.1038/s12276-021-00687-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Cumulated data of glucose uptake (left panel) and lactate production assays (right panel) in Panc-1pLKO and Panc-1shKLF10 cells. Data are presented as the mean ± SE (* signifies p < 0.05). The experiments were repeated three times. b Representative oxygen consumption rate in Panc-1pLKO (black) and Panc-1shKLF10 (gray) cells in response to oligomycin, carbonyl cyanide-p-trifluoromethoxyphenyl-hydrazon (FCCP), antimycin A (antiA), and rotenone (Rot). The results were normalized according to cell number and are presented as the mean ± SE (n = 3). c Basal and maximal respiration were determined in the same experimental setting for Panc-1pLKO and Panc-1shKLF10 cells in (b). d Representative immunoblots of KLF10 and glycolytic enzyme expression in Panc-1pLKO and Panc-1shKLF10 cells with and without KLF10 replacement. β-Actin was used as the internal control. Quantitative analysis of at least three independent experiments is shown beside the immunoblots. e Cumulated lactate production assay data of Panc-1pLKO and Panc-1shKLF10 cells with and without KLF10 replacement. Data are presented as the mean ± SE (* signifies p < 0.05). f Representative hematoxylin and eosin (H&E) staining and immunohistochemistry of KLF10, PKM2, and PDK1 in nontumor normal pancreas and pancreatic tissues (×100 and ×400 for the middle and right panels, respectively) from patients with curatively resected PDAC. g Correlation of immunolabeling of KLF10 with PKM2 from the pancreatic tissues of 10 patients from the cohort mentioned in the “Materials and methods” section of PDAC patients who underwent curative resection. The correlation coefficient = −0.5, p = 0.011. h Representative six databases from Oncomine with correlated levels of KLF10 and PKM2 transcripts.