TABLE 3.

pNfL and cNfL levels according to the accuracy level of the categories of the Revised El Escorial diagnostic criteria and to genetic status (i.e., wild type vs. ALS gene mutations).

Revised El Escorial criteria	N	pNfL Median (IQR)	N	cNfL Median (IQR)
Possible ALS	38	64.9 (27.6–101.3)	25	4536 (2232–8853)
Probable laboratory-supported ALS	31	45.8 (31.4–70.7)	24	5100 (3145.2–7760)
Probable ALS	68	86.1 (57.7–127.2)	45	7572 (4770–15569)
Definite ALS	31	100.5 (58.8–135.5)	19	10892.4 (6156–14629)
Genetic status	N	pNfL Median (IQR)	N	cNfL Median (IQR)
Wild-type	137	73.5 (43.9–113.7)	98	6317 (3574–13476)
SOD1	6	36.0 (14.0–59.4)	2	2252; 4536
TARDBP	2	32.8; 51.8	1	3018.5
FUS	1	37.2	0	NA
C9Orf72	18	107.1 (64.5–125.3)	11	10796 (7950–12031)

Biomarker values are expressed in pg/ml. Key: ALS, amyotrophic lateral sclerosis; cNfL, cerebrospinal neurofilament light chain; IQR, interquartile range; N, number; NA, not available; pNfL, plasma neurofilament light chain.