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. 2019 Nov 14;45(6):642–653. doi: 10.1016/j.jgr.2019.09.003

Fig. 7.

Fig. 7

Effects of LY294002 and SB203580 on GP-17–induced cardioprotective effects in Langendorff rat hearts. The hearts with or without 15 min of GP-17 (20μM) preprocessing were exposed to LY or SB for 15 min. (A) The improved function of GP-17 on heart LVSP, LVeDP, heart rate, +dp/dtmax, and −dp/dtmin were suppressed by inhibitors LY and SB; (B) immunoblot analysis of the protein expression levels in Langendorff rat hearts; (C–E) bar graphs showed the relative protein expressions of Grp78, CHOP, PI3K, AKT, P38, JNK, and Bcl-2 were expressed in the #P < 0.05 versus the control, ##P < 0.01 versus the control, ###P < 0.001 versus the control, *P < 0.05 versus the I/R group, **P < 0.01 versus the I/R group, ***P < 0.001 versus the I/R group.GP-17, gypenoside XVII; LVSP, left ventricular systolic pressure; LVeDP, left ventricular end-diastolic pressure; I/R, ischemia and reperfusion.