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Score 2b in squamous cell carcinoma. A. An example of squamous cell carcinoma stained with hematoxylin & eosin, showing the malignant cell nuclei with prominent nucleoli. B. CTLA-4 stain of the same case showing a moderate cytoplasmic granular reaction (2+ intensity) involving more than 90% of the cells, scored as “2b”, and interpreted as “Positive” (40× objective).
