Table 1.

Summary of cores with interpretive positivity of the immune checkpoints in the groups and subgroups of uterine cervical carcinoms and related statistical analysis results

Group	Carcinoma	Median Age	Total (n)	CTLA-4			CTLA-4		CD137
				Positive (n)			Positive (%)		Positive (%)
Control	Benign	57	4	0			0%		25%
Group I
Squamous cell carcinomas, all		44	74	23			31%		91%
	IA-SCC, grade I	46	7	3			43%		86%
	IB-SCC, grade II	44	52	16			31%		96%
	IC-SCC, grade Ill	39	15	4			27%		73%
Group II
Adenosquamous carcinoma		40	8	5			63%		88%
Group III
Endocervical adenocarcinoma		40	13	2			15%		100%
Groups I, II, and III		44	95	30			32%		91%
Student’s t-test: “Benign” versus Group I, II, and III (two-tailed, unequal variance): CTLA-4: P-value <0.0001, CD137: P-value =0.075.
2×2 table Fisher Exact statistical tests (CTLA-4)			Negative (n)		Positive (n)			2-Tailed P-Value
SCC, grade I			4			3		0.67
SCC, grade II			36			16
SCC, grade II			36			16		1.0
SCC, grade III			11			4
SCC, grade I			4			3		0.63
SCC, grade III			11			4
SCC, all grades			51			23		0.12
Adenosquamous carcinoma			3			5
SCC, all grades			51			23		0.33
Endocervical adenocarcinoma			11			2
Adenosquamous carcinoma			3			5		0.056
Endocervical adenocarcinoma			11			2

SCC, squamous cell carcinoma; Positive includes “1b”, and “2b” scores.