Rg1 treatment alleviated neuronal damage in cortex and hippocamppus in APP/PS1 mice. (A) The results of H&E staining (Hippocampus 100 × , the bar = 100 μm; Cortex 400 × , the bar = 20 μm, n = 5). The red boxes indicate Aβ deposition areas. (B) The results of Nissl staining in the cortex, hippocampus CA1 and CA3 (400 × , the bar = 20 μm, n = 5); (C) The mean density of Nissl bodies in the cortex, hippocampus CA1 and CA3. (D) The bands and relative expression of β-Gal over WT-9M (Western blot, n = 4). Results are expressed as mean ± SD. ∗P < 0.05, ∗∗P < 0.01 vs WT-9M group; #P < 0.05, ##P < 0.01 vs APP/PS1-6M group; ΔP<0.05, ΔΔP<0.01 vs APP/PS1-9M group.