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Progression from healthy arteries to complicated lesions. FDG and NaF uptake have long been known to precede vascular calcification evident on CT and intravascular ultrasonography (IVUS). The paradigm shift is the stronger predictive power of NaF uptake and the occurrence of active calcification measured by NaF uptake in early coronary fatty streaks and preatheroma (CAC coronary artery calcium) (Reproduced with permission from McKenney-Drake ML et al.) [39].
