Table 2.
DDX5 outgoing signal network*: DDX5 downstream targets
| Mechanism and Effects | Classified Molecules |
|---|---|
| 1. Molecules that DDX5 binds on for activation | Transcription factor: Androgen receptor, c-Fos, CTCF, ESR1 (nuclear), GATA-6, MYOD, NF-AT5, NF-kB1 (p50), NOTCH1 (NICD), p53, RBP-J kappa (CBF1), RUNX2, SRF, STAT3, c-Myc, HES1. Generic binding protein: Beclin 1, b-catenin, Cyclin A2, Cyclin B2, Cyclin D2, hnRNP A2, Rev (HIV1), SUZ12, Bax, Bcl-XL, CDC20, Cyclin D1. Generic enzyme: CBP, DROSHA, G9a, RAD18, Rad50, XRN2. Generic RNA: microRNA let-7a-1. Generic protein: NSSB (HCV). |
| 2. DDX5 co-regulated molecules for transcription activation | Protein kinase: AKT1. Generic binding protein: Bax, Bcl-XL, CDC20, Cyclin D1, Mcl-1, <TS1 (S100A4), ORC6L, p21, PUMA, Stanniocalcin 1. Transcription factor: c-Myc, HES1, MEF2C, MYOG, NFAT-90, SLUG, SNAIL1. Receptor ligand: IL-1 beta, IL-20, VEGF-A, WNT5A. Generic receptor: IL-2R alpha chain. Generic protease: Kallikrein 3 (PSA). Generic RNA: microRNA 181b-1, microRNA 21. Metalloprotease: MMP-2, MMP-9. |
| Transporter: NGAL. Protein Kinase: PLK1. Generic protein: TMEM26. Generic enzyme: TMEM55B. | |
| 3. Molecules that DDX5 binds on for inhibition | RAS superfamily: H-Ras. Generic RNA: microRNA 182, microRNA 196a-2, microRNA 34a. Generic binding protein: Myelin basic protein, Sequestosome 1 (p62). |
| 4. DDX5 co-regulated molecules for transcription inhibition | Transcription factor: C/EBPdelta, KLF4. Voltage-gated ion-channel: CLCA2. Generic binding protein: Ep-CAM, p15. |
| 5. Molecules that DDX5 competes with for inhibition | Generic binding protein: Axin1. |
| 6. Molecules that DDX5 binds on with unspecified effects | Generic enzyme: AARS, ARSL, ADAR1, AMP deaminase 1, ATP8B3, C1TM, C6orf150, CGAT1, CHD5, CYP2A13, CYP4B1, DDX1, DDX17, DDX21, DDX23, DDX24, DDX9, DHX8, DNA ligase IV, eIF2C2 (Argonaute-2), Fibrillarin, FTHC, FTSJ3, HDAC1, HDC, KAR, Lactoperoxidase, METTL3, MOZ, MPG, NS5 (JAEV), PAM, Parvulin 14, PB1 polymerase 1 (Influenza A virus), PDE1C, PDE3B, PDE8B, PISD, POLR2A, PON3, RNA polymerase II, RNMT, RPP38, SATL1, SIA10, SMURF1, TPH1, UGT2A1, XPB, XYLT1. Generic binding protein: ACTL7A, Amyloid beta 42, ANKS1, Ankyrin-B, APC protein, ARC, ARID4A, ASB1, BAT2, C2orf63, CacyBP (SIP), CAMSAP1, CAPZ beta, CAS-L, CBP80, CCAR1, CENP-F, CMTR1, CNOT1, CNTN5, CRFG (NGB), Cyclin A1, Cyclin D3, Cyclin E, Cyclin T1, D52, DAZ2, DEDD, DOM3Z, DZIP, E6 protein (HPV16), ECM29, EED, EEF1E1, eIF2C1 (Argonaute-1), ELAVL1 (HuR), Epiplakin, FAM136A, FAT1, FAT2, FLJ43093, FRYL, GAS11, Gemin5, Hampin, HC II, Hdj-2, Histone H2AX, hnRNP C, HYOU1, IGF2BP3, IRF2BP1, KBTBD5, L-Ficolin, Lba1, LMAN1L, MBD3, MCM10, Mi-2, Mi-2 alpha, Midasin, MKLP1, MYH9, MYL6, Myoglobin, Myosin VIIA, NANOS3, NIPBL, NLRC5, Nop56, Nop58, NP (Influenza A virus), Nucleolin, Oviductin, PABPC1, PES1, Plectin 1, PLEKHA4, PML, RENT1, RENT2, RENT3B, RHOBTB1, RPL10A (CsA-19), RPL13, RPL17, RPL21, RPL26, RPL4, RPL6, RPL7, RPL7A, RPLP0, RPS19, RPS3, RPS3A, RPS9, SAMD13, SEC23A, Sec24C, Septin 4, Serpin B12, SETBP1, SFRS3, SHRM, SMG7, SNX11, SON, SSX5, TANC, Tangerin A, Tau (MAPT), TCP1-eta, TPX2, TRAF5, TSPEAR, ZBTB12, ZNF294, ZNF462, ZNF699, ZNF77, ZNF804B, ZSWIM3. Metalloprotease: ADAM12, SUPT16H. Protein Kinase: AKT2, AKT3, ATM, ATR, Aurora-C, CaMK II alpha, CDKL5, HIPK3, JNK1 (MAPK8), JNK3 (MAPK10), MEK4 (MAP2K4), MYLK1, p90RSK2 (RPS6KA3), RIPK2, SIK, SLK, TAK1 (MAP3K7), Titin, TTK. Ligand-gated ion-channel: ANO7. Generic channel: ATP8B4. Generic protein: C (HCV), C13orf39, C14orf104, C21orf54, C5orf35, XXSX62, Core protein (JAEV), CSPP1, DKFZP434B061, FAM33A, FBF1, FBXW10, FLJ10986, FLJ13231, FLJ14803, KIAA0774, KIAA1109, KIAA1211, KIAA1704, KIAA1731, LL5beta, LSMD1, LZTS2, MLLT11, MNS1, MUM1, NS4B (HCV1b), OSBPL7, SNM1, SPECC1, ST20, SYCP2L, TMEM98, VN1R17P, WDR48. Transcription factor: c-Jun, EBF2, ELYS, FALZ, Fra-1, HEY2, MEIS1, NF45 (ILF2), PXR, RUNX3, SMAD1, SMAD2, SMAD4, SMAD7, STAT1, TBP, TIEG1, TLE4, UNR, ZNF145, ZNF384. Lipid kinase: DGK-zeta. |
| eneric DNA: DNA. Receptor ligand: Galanin, IFN-omega, LAMA2, PACAP, TNF-alpha. GPCR: Gpr123. Generic RNA: HOTAIR, Hotair (mouse), microRNA 145, microRNA 15-1, microRNA 214, microRNA517B, microRNA let-7g, miR-483-5p, mRNA intracellular, RNA. Generic receptor: IL7RA, RELT. | |
| Transporter: IPO11, Karyopherin alpha 6, Rabphilin-3A, SLC21A2, SLC4A2. Regulators (GDI, GAP, GEF, etc.): IQSEC2, LARG, RGS5, SOS2. Voltage-gated ion-channel: Nav1.6. Generic protease: NS3 (JAEV), S1P, SFRS2 (SC-35), Usp24, USP6, USP7. | |
| Generic kinase: PKM2. Protein phosphatase: PP2A cat (beta), SHP-1. RAS superfamily: Rab-32, Rab12, RAB2B. | |
| 7. DDX5 transcriptionally co-regulated molecules with unspecified effects | Metalloprotease: ADAM-TS20. Generic enzyme: AMDHD2, CL6S, HEXA, HHIPL2, Spam1, TERT, ZNRF3. Generic channel: ATP6V1H. Transcription factor: BACH2, MESP2, RARgamma, RLF, Scieraxis, SOX8, TSC-22. Generic binding protein: Cadherin 9, CDC4L, MAEL, MRLPL32, Prickle-1, SERPINB8, SP3A3, SLAP-2, SPAG16, SSX2IP, TFF1, Thrombospondin 4. |
| Ligand-gated ion-channel: GABA-A receptor gamma-2 subunit, GluR6. Receptor ligand: IGF-2, Vitronectin. Voltage-gated ion-channel: KCNH7, KCNQ5. Protein kinase: KSR1. Receptor ligand: LAMB3. Generic protein: LAMP1, MAGEB16, ODZ4, Paralemmin, STOX2. Generic receptor: Neurexin 1-alpha, Neurexin 1-beta, PTCH2. Generic protease: PRSS11 (HtrA1). RAS superfamily: RAB40B. |
*
Information was retrieved from the GeneGo database at https://portal.genego.com/and organized by the authors.
Relevant references for each finding can be found in the database from the corresponding molecule under the “Interaction info”.