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. 2021 Oct 15;11(10):4788–4806.

Figure 8.

Figure 8

DKK1 increased tumorigensis in the transgenic mouse model. A. DNA mixtures were injected into the lateral tail veins of 4-week-old mice and the livers were harvested at 9 weeks. B. Forced expression of DKK1 with HRAS in transgenic mouse liver resulted in the formation of more tumors (n=5), compared to the controls. C, D. H&E and IHC staining for HRAS, Ki-67, p-Akt and p-VEGFR2 on serial paraffin sections of HI_Luc2A and HI_DKK1 tumors (magnification, 200 ×). E. Lysates of HI_Luc2A and HI_DKK1 tumors were probed with the indicated antibodies. GAPDH was used as a loading control.