Figure 5.
Alternative splicing and angiogenesis. A. VEGFA forms VEGFA××× and VEGFA×××b isoforms via alternative splicing. SRSF1 and SC35 (also known as SRSF2) promote formation of the two VEGFA isoforms and these splicing factors are regulated by other proteins and non-coding RNA, which indirectly affect the splicing of VEGFA. B. Regulation of angiogenesis by different splicing isoforms of VEGFR and VASH1. ID4, inhibitor of DNA binding 4; SRPK1, SRSF growth factor 1; E2F1, E2F transcription factor 1; VEGFA, vascular endothelial growth factor A; VEGFC, vascular endothelial growth factor C; VEGFR1, vascular endothelial growth factor receptor 1; VEGFR2, vascular endothelial growth factor receptor 2; sVEGFR2, soluble VEGFR2; VASH1A, vasohibin 1 A isoform; VASH1B, vasohibin 1 B isoform.